The Centre for Health Protection has learned of two avian influenza A (H7N9) cases in Zhejiang.
The patients are a 62-year-old woman in Shengzhou and a 51-year-old woman farmer in Hangzhou.
They had been exposed to poultry and are in serious condition.
Four cases have been reported on the Mainland since October, all from Zhejiang.
There have been 661 H7N9 cases reported by Mainland health authorities since 2013.